TB-500
Also known as: Thymosin Beta-4, Tβ4
TB-500 is a synthetic fraction of the protein Thymosin Beta-4, which is naturally present in most human cells. It is widely investigated for its potential to promote healing, decrease inflammation, and improve cell migration and differentiation.
Molecular Properties
Molecular Formula
C212H350N56O78S
Molecular Weight
4963.44
CAS Number
77591-33-4
Research History
Thymosin Beta-4 was first discovered in the thymus gland, but its systemic roles in wound healing were only fully characterized in the late 20th century. TB-500 was developed as a more stable, smaller peptide fragment to replicate the therapeutic effects of the endogenous protein.
Studied Mechanisms
The primary mechanism involves the upregulation of actin, a protein vital for cell movement and structural integrity. By promoting actin polymerization, TB-500 facilitates cellular migration to injury sites, thereby accelerating wound closure and tissue recovery while reducing scarring.
Storage Reference
Lyophilized: Store at -20°C. Reconstituted: Store at 4°C for short-term, -20°C for long-term.
Handling Reference
Handle with appropriate PPE. Use aseptic technique. Keep away from light.